
PLRX Stock Forecast & Price Target
PLRX Analyst Ratings
Bulls say
Pliant Therapeutics Inc. is focused on developing its leading candidate, bexotegrast (PLN-74809), for treating idiopathic pulmonary fibrosis and primary sclerosing cholangitis, demonstrating potential efficacy in both indications. The company's strategy of utilizing integrins αvβ8 and αvβ1 for a more localized blockade of TGF-β may enhance safety and effectiveness, particularly as it plans to initiate new Phase 2b studies to optimize dosages for IPF. The promising early data from the clinical trials, along with the emphasis on improving the risk-benefit profile of bexotegrast, positions Pliant favorably in the biopharmaceutical landscape.
Bears say
Pliant Therapeutics has announced the discontinuation of its BEACON-IPF Phase 2b trial for bexotegrast due to a safety-related imbalance, specifically citing a lower-than-expected incidence of IPF-related adverse events in the placebo group. The company reported a substantial net loss of $49.7 million for Q4 2024, indicating challenges in translating early efficacy signals into viable commercial opportunities, particularly following the termination of a key program aimed at a significant indication. Furthermore, the pipeline appears limited beyond the halted IPF program, suggesting a lack of immediate catalysts to drive value for investors in the near term.
This aggregate rating is based on analysts' research of Pliant Therapeutics and is not a guaranteed prediction by Public.com or investment advice.
PLRX Analyst Forecast & Price Prediction
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